Over the past decade, civil society has played a pivotal role in the fight against trafficking in persons. A multifaceted and complex phenomenon, trafficking in persons must be addressed at various levels. Members of civil society have worked alone or by joining forces with law enforcement groups, legislators, national governments, and international organizations while designing strategies of prevention, protection, prosecution, advocacy, and research. The Protection Project encourages the dissemination of information about the best ways to combat trafficking in persons by recommending five main components of civil society: (a) nongovernmental organizations (NGOs), (b) corporations, (c) academia, (d) media, and (e) faith-based organizations. The Protection Project’s 100 Best Practices in Combating Trafficking in Persons: The Role of Civil Society offers examples of some successful initiatives that have been undertaken by representatives of those five main categories. This publication is intended to serve as a guide in the design and implementation of anti-trafficking practices worldwide, as well as to inform the general public about outstanding contributions to the fight against trafficking in persons.